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More than 75% of all newly diagnosed patients with adult HL can be cured with combination chemotherapy and/or radiation therapy. National mortality has fallen more rapidly for adult HL than for any other malignancy over the last 5 decades. Prognosis for a given patient depends on several factors.
With a median follow-up of 9.8 years, the median PFS was 3.0 years for patients who received rituximab induction only and 5.6 years for patients who received rituximab induction plus rituximab maintenance.[Level of evidence: 3iii Diii] With induction only, 9 of 23 patients relapsed with an aggressive B-cell lymphoma.Um die volle Funktionalität der Seite zu nutzen, müssen Sie die Darstellung von Flash-Inhalten in Ihrem Browser erlauben.Bitte klicken Sie auf den "Kippschalter", um Flash für Ihren Browser zu aktivieren.Other important factors are age, sex, erythrocyte sedimentation rate, extent of abdominal involvement, hematocrit, and absolute number of nodal sites of involvement.[3-5] HL is the main cause of death over the first 15 years after treatment.By 15 to 20 years after therapy, the cumulative mortality from a second malignancy will exceed the cumulative mortality from HL.[6-8] Pathologists currently use the World Health Organization (WHO) modification of the Revised European-American Lymphoma (REAL) classification for the histologic classification for adult Hodgkin lymphoma (HL).[1,2] Nodular lymphocyte–predominant HL (NLPHL) is a clinicopathologic entity of B-cell origin that is distinct from classic HL.[4-6] The typical immunophenotype for lymphocyte-predominant disease is CD15-, CD20 , CD30-, CD45 , while the profile for classic HL is CD15 , CD20-, CD30 , CD45-.